Hepatitis C Virus Replication Compartment Formation: Mechanism and Drug Target
نویسندگان
چکیده
منابع مشابه
Hepatitis C virus and skin
Nowadays viral hepatitis is one of the most common and important causes of chronic liver disorders in the world. Extrahepatic manifestations of viral hepatitis consist a main part of the disease. The main viruses causing hepatitis include Hepatitis A, B and C viruses. Herein common skin manifestations in hepatitis C virus (HCV) are discussed. Chronic hepatitis causes skin disorders both directl...
متن کاملReplication of hepatitis C virus.
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متن کاملMorphological and biochemical characterization of the membranous hepatitis C virus replication compartment.
Like all other positive-strand RNA viruses, hepatitis C virus (HCV) induces rearrangements of intracellular membranes that are thought to serve as a scaffold for the assembly of the viral replicase machinery. The most prominent membranous structures present in HCV-infected cells are double-membrane vesicles (DMVs). However, their composition and role in the HCV replication cycle are poorly unde...
متن کاملMorphological and biochemical characterization of the 4 membranous hepatitis C virus replication compartment
1 1 2 3 Morphological and biochemical characterization of the 4 membranous hepatitis C virus replication compartment 5 6 7 David Paul, Simone Hoppe, Gesine Saher, Jacomine Krijnse-Locker, and Ralf 8 Bartenschlager 9 10 Department of Infectious Diseases, Molecular Virology, Heidelberg University, Im 11 Neuenheimer Feld 345, 69120 Heidelberg, Germany 12 Electron Microscopy Core Facility, Heidelbe...
متن کاملHepatitis C Virus and Vaccine Development
The prevalence of Hepatitis C virus (HCV) is approximately 3% around the world. This virus causes chronic hepatitis, liver cirrhosis and hepatocellular carcinoma. The effectiveness of interferon-α and ribavirin therapy is about 50% and is associated with significant toxicity and cost. Hence, generating new vaccines or drugs is an obligation. However, there is no vaccine available for clinical u...
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ژورنال
عنوان ژورنال: Gastroenterology
سال: 2014
ISSN: 0016-5085
DOI: 10.1053/j.gastro.2014.03.017